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Bronchial lavage in cystic fibrosis. A comparison of agents
Cezeaux G Jr, Telford J, Harrison G, Keats AS
JAMA 1967 Jan 2;199(1):73-76
clinical trial
5/10 [Eligibility criteria: No; Random allocation: No; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: Yes; Blind therapists: No; Blind assessors: No; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

The relative benefits and hazards of bronchial lavage with 10% acetylcysteine (Mucomyst) compared to sodium chloride solution was studied in 14 patients with cystic fibrosis who were treated on 16 occasions. Lavage with acetylcysteine produced a significant increase in arterial carbon dioxide tension (Paco2) and a decrease in arterial oxygen tension (Pao2) immediately after lavage. Lavage with sodiun chloride solution produced a decrease in Paco2 and increase in Pao2. Regardless of lavage agent, pulmonary function was impaired for 48 to 72 hours after lavage, and three patients developed pneumonia within three days after lavage. When bronchial lavage was used as one part of a complete therapeutic program, some improvement in pulmonary function could be demonstrated two to six weeks after therapy.

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