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Improvement of BMI, body composition, and body fat distribution with lifestyle modification in Japanese Americans with impaired glucose tolerance
Liao D, Asberry PJ, Shofer JB, Callahan H, Matthys C, Boyko EJ, Leonetti D, Kahn SE, Austin M, Newell L, Schwartz RS, Fujimoto WY
Diabetes Care 2002 Sep;25(9):1504-1510
clinical trial
3/10 [Eligibility criteria: No; Random allocation: Yes; Concealed allocation: No; Baseline comparability: No; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

OBJECTIVE: To determine whether diet and endurance exercise improved adiposity-related measurements in Japanese Americans with impaired glucose tolerance (IGT). RESEARCH DESIGN AND METHODS: This study compared the effects of an American Heart Association (AHA) step 2 diet (< 30% of total calories as fat, < 7% saturated fat, 55% carbohydrate, and < 200 mg cholesterol daily) plus endurance exercise for 1 h three times a week (treatment group) with an AHA step 1 diet (30% of total calories as fat, 10% saturated fat, 50% carbohydrate, and < 300 mg cholesterol) plus stretching exercise three times a week (control group) on BMI, body composition (% fat), and body fat distribution at 6 and 24 months of follow-up in 64 Japanese American men and women with IGT, 58 of whom completed the study. RESULTS: At 6 months, the treatment group showed significantly greater reduction in percent, body fat (-1.4 +/- 0.4 versus -0.3 +/- 0.3%); BMI (-1.1 +/- 0.2 versus -0.4 +/- 0.1 kg/m2); subcutaneous fat by computed tomography at the abdomen (-29.3 +/- 4.2 versus -5.7 +/- 5.9 cm2), thigh (-13.2 +/- 3.6 versus -3.6 +/- 3.0 cm2), and thorax (-19.6 +/- 3.6 versus -8.9 +/- 2.6 cm2); and skinfold thickness at the bicep (-2.0 +/- 0.6 versus 1.1 +/- 0.6 mm) and tricep (-3.7 +/- 0.8 versus -0.9 +/- 0.6 mm), which continued despite moving to home-based exercise for the last 18 months. CONCLUSIONS: Diet and endurance exercise improved BMI, body composition, and body fat distribution and, thus, may delay or prevent type 2 diabetes in Japanese Americans with IGT.
Copyright American Diabetes Association. Reprinted with permission from The American Diabetes Association.

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