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Glucosamine in serum of patients after myocardial infarction subjected to rehabilitation training
Nowak A, Szczesniak L, Rychlewski T, Dylewicz P, Karolkiewicz J
Journal of Physiology and Pharmacology 1998 Jun;49(2):293-301
clinical trial
4/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

This paper presents results of 3 weeks physical training on glucosamine level in serum of male patients after myocardial infarction (MI) aged between 38 and 61. Patients were randomised in two groups: the training group (n = 21), staying in Cardiac Rehabilitation Department and the control group (n = 11), discharged home for 3 weeks. Each group received identical dietary instructions. The training group performed exercises every day: on bicycle ergometer during 30 minutes (5 times a week), overall-conditioning exercises for 30 minutes daily and 30 to 60 minutes of walking each day. Before administering of the therapy and 3 weeks later all MI patients performed the bicycle ergometer exercise test until the ventilatory threshold was reached. Before that test and 3 minutes after its termination capillary and venous blood samples were drawn. In the capillary blood samples indices of acid-base balance, lactate level, and glucose level were determined. In venous blood samples the serum levels of immunoreactive insulin, C-peptide and glucosamine were determined as well as binding of 125I-insulin to erythrocyte receptors. Obtained results show that administered therapy increased physical fitness and decreased of glucosamine concentration, insulinaemia and insulin resistance.

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