AIM: To observe the influence of exercise prescription on the body mass, blood glucose and insulin in overweight or obese type 2 diabetic patients. METHODS: (1) Fifty overweight or obese type 2 diabetic patients aged 30 to 65 years with the disease course of 1 to 5 years were selected from the Department of Endocrinology, Liaocheng People's Hospital between December 2002 and December 2004. They were randomly divided into study group (n = 25) and control group (n = 25). (2) All the patients were given routine drug therapy for 6 months, besides those in the study group received exercise therapy at the same time. The exercise therapy consisted of walking, alteration of walking and running, jogging, dancing with kicking the shuttlecock, etc. (3) The body mass index (body mass (kg)/body height (m2)) and waist-to-hip ratio were calculated. Before and after therapy, blood glucose was detected with peroxidase, insulin with radioimmunoassay, and glycosylated hemoglobin A with affinity chromatography. (4) The results were compared and analyzed with the t test and analysis of covariance between the two groups. RESULTS: All the 50 overweight or obese type 2 diabetic patients were involved in the analysis of results. Fasting blood glucose, glycosylated hemoglobin A, 2-hour postprandial glucose, body mass index, waist-to-hip ratio, fasting insulin and postprandial insulin in the study group after therapy were obviously lower than those before therapy and those in the control group after therapy (p < 0.05 to 0.01). Fasting insulin and postprandial insulin in the control group after therapy were obviously lower than those before therapy (22.67 +/- 3.39, 72.84 +/- 7.78 mIU/L; 25.54 +/- 5.93, 82.18 +/- 9.43 mIU/L, p < 0.05, 0.01). CONCLUSION: Exercise prescription can reduce the body mass and ameliorate the related indexes of diabetes mellitus in obese type2 diabetic patients.

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