AIM: To observe the influence of moderate-intensity exercise on the plasma level of adiponectin, insulin sensitivity and body mass of obese patients with type 2 diabetes mellitus. METHODS: (1) Forty-five obese patients with type 2 diabetes mellitus (31 males and 14 females), who were treated in the Department of Endocrinology, Union Hospital affiliated to Fujian Medical University between March 2002 and October 2004, were randomized into exercise group (n = 23) and control group (n = 22). (2) The patients in the control group received routine treatment of dietary control and decreasing plasma glucose. Besides those in the exercise group participated in a 16-week exercise program of moderate intensity by means of jogging, 3 times a week, 60 minutes for each time, obtaining 60% of the maximal heat rate was regarded as a standard, and every repetition lasted for 10 minutes at least. (3) The physical parameters related to obesity (including waistline and BMI) were measured before and after intervention, body mass index was calculated (body mass index = body mass (kg)/body height (m2)). The fasting plasma glucose and glycosylated hemoglobin were detected with Beckman CX7 automatic biochemical analyzer. The fasting insulin was determined with magnetic affinity immunoassay (MAIA). Insulin sensitivity index (ISI) was calculated (ISI = fasting plasma glucose/fasting insulin). The plasma level of adiponection was detected following the instruction of immunoassay kit. (4) The t test and Chi2 test were applied in the intergroup comparison of measurement data and enumeration data. RESULTS: All the 45 obese patients with type 2 diabetes mellitus were involved in the analysis of results. (1) Physical parameters: the waistline and body mass index in the exercise group before intervention and those in the control group after intervention were all obviously higher than those in the exercise group after intervention (t = 3.335 to 8.075, p < 0.05 to 0.01). (2) Blood biochemical indexes: there were insignificant differences in the blood biochemical indexes between the two groups before intervention (p > 0.05). In the exercise group, the fasting plasma glucose, fasting insulin and glycosylated hemoglobin after intervention were all obviously lower than those before intervention, but ISI was markedly higher than that before intervention (t = 3.948 to 11.423, p < 0.01). After intervention, the fasting insulin was obviously lower in the exercise group than in the control group (t = 2.679, p < 0.05), ISI was obviously higher in the exercise group than in the control group (t = 5.131, p < 0.05). In the control group, the fasting plasma glucose and glycosylated hemoglobin after intervention were obviously lower than those before intervention (t = 9.504, 8.515, p < 0.01). (3) Plasma level of adiponection: there was no obvious difference between the two groups before intervention (p > 0.05). The plasma level of adiponection in the exercise group after intervention was obviously higher than that before intervention and that in the control group after intervention (t = 4.983, p < 0.01; t = 2.429, p < 0.05). In the control group, it was insignificantly higher after intervention than before intervention (p > 0.05). CONCLUSION: The moder ate-intensity exercise can improve the insulin sensitivity of obese patients with type 2 diabetes mellitus, it is good for the stability of plasma glucose, which is possibly correlated with the increased level of plasma adiponection.

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