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The biostimulative effect of low level laser therapy of long-standing crural ulcers using helium neon laser, helium neon plus infrared lasers, and noncoherent light: preliminary report of a randomized double blind comparative study
Bihari I, Mester AR
Laser Therapy 1989;1(2):97-98
clinical trial
5/10 [Eligibility criteria: No; Random allocation: Yes; Concealed allocation: No; Baseline comparability: No; Blind subjects: Yes; Blind therapists: No; Blind assessors: Yes; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: No; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

Forty-five patients with crural ulcers resistant to conventional therapy were divided into three groups randomly by age (n = 15). Group 1 was treated with a hand-held helium neon (HeNe) laser; group 2 with a machine-scanned combined HeNe and infrared (pulsed, 904 nm) laser; and group 3 with noncoherent unpolarized red light. All three groups received approximately equal dosage. An additional fourth group of patients (n = 5) with recurrent ulcers was treated with the machine-scanned HeNe/pulsed infrared laser system. Groups 1 and 2 demonstrated excellent healing, with group 2 slightly better than group 1, compared to group 3 with a low effective percentage. Of the group 4 patients with recurrent ulcers, all five healed after repeat treatments. The combination of the HeNe laser with infrared appeared more efficient than HeNe laser alone, but both were much more efficient than noncoherent red light.

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