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Multidisciplinary rehabilitation for subacute low back pain: graded activity or workplace intervention or both: a randomized controlled trial [with consumer summary]
Anema JR, Steenstra IA, Bongers PM, de Vet HC, Knol DL, Loisel P, van Mechelen W
Spine 2007 Feb 1;32(3):291-298
clinical trial
7/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: Yes; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: Yes; Intention-to-treat analysis: Yes; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

STUDY DESIGN: Population-based randomized controlled trial. OBJECTIVE: To assess the effectiveness of workplace intervention and graded activity, separately and combined, for multidisciplinary rehabilitation of low back pain (LBP). SUMMARY OF BACKGROUND DATA: Effective components for multidisciplinary rehabilitation of LBP are not yet established. METHODS: Participants sick-listed 2 to 6 weeks due to nonspecific LBP were randomized to workplace intervention (n = 96) or usual care (n = 100). Workplace intervention consisted of workplace assessment, work modifications, and case management involving all stakeholders. Participants still sick-listed at 8 weeks were randomized for graded activity (n = 55) or usual care (n = 57). Graded activity comprised biweekly 1-hour exercise sessions based on operant-conditioning principles. Outcomes were lasting return to work, pain intensity and functional status, assessed at baseline, and at 12, 26, and 52 weeks after the start of sick leave. RESULTS: Time until return to work for workers with workplace intervention was 77 versus 104 days (median) for workers without this intervention (p = 0.02). Workplace intervention was effective on return to work (hazard ratio = 1.7; 95% CI 1.2 to 2.3; p = 0.002). Graded activity had a negative effect on return to work (hazard ratio = 0.4; 95% CI 0.3 to 0.6; p < 0.001) and functional status. Combined intervention had no effect. CONCLUSION: Workplace intervention is advised for multidisciplinary rehabilitation of subacute LBP. Graded activity or combined intervention is not advised.
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