AIM: To observe the changes of the level that plasma tumor necrosis factor (TNF) and receptor in heart failure (CHF) patients and the effects of walking movement on them so as to investigate the treatable value of walking movement for CHF patients. METHODS: The 81 patients with CHF (their cardiac function were 11 or 111 stage) were randomly divided into 2 groups: movement treatment group (treat by routine treatment and motortherapy n = 48) and control group (routine treatment n = 33). The methods of motortherapy: The patients made the walking movement for 6 min in the morning and afternoon everyday for 8 weeks. All of the patients were drew the venous blood from the cubitus before and after they were hospitalized at the after walking movement beginning of the treatment. The levels of TNF-a and STNFR in the blood plasma were assayed. RESULTS: At the beginning of the treatment, 81 patients' walking movement than the levels of TNF-a and STNFR before the walking movement (t = 2.730, p < 0.01). The levels of TNF-a and STNFR in the blood plasma were obviously reduced after all the patients had been given the treatment for 8 weeks (t = 2.437, p < 0.05), and the patients levels of TNF-a and STNFR in the group of movement treatment were obviously reduced before the movement compared with the group of control. All of the patients could do a longer distance of walking than they did not have the treatment, but the group of movement treatment could have a much longer distance of walking than the group of contrast (t = 2.530, p < 0.05). CONCLUSION: The patients with CHF make the rational movement every day, the content of inflamma cell in the patients plasma can be effectively reduced and the movement also is good at the patients recovery.

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