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Effects of aerobic training during hemodialysis on heart rate variability and left ventricular function in end-stage renal disease patients
Reboredo MM, Pinheiro BV, Neder JA, Avila MPW, Araujo Ribeiro ML, de Mendonca AF, de Mello MV, Bainha ACC, Dondici Filho J, de Paula RB
Jornal Brasileiro de Nefrologia 2010 Dec;32(4):367-373
clinical trial
5/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: Yes; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

INTRODUCTION: Decreased heart rate variability (HRV) in patients with end stage renal disease (ESRD) undergoing hemodialysis is predictive of cardiac death, especially due to sudden death. OBJECTIVE: To evaluate the effects of aerobic training during hemodialysis on HRV and left ventricular function in ESRD patients. METHODS: Twenty two patients were randomized into two groups: exercise (n = 11; 49.6 +/- 10.6 years; 4 men) and control (n = 11; 43.5 +/- 12.8; 4 men). Patients assigned to the exercise group were submitted to aerobic training, performed during the first two hours of hemodialysis, three times weekly, for 12 weeks. HRV and left ventricular function were assessed by 24 hours Holter monitoring and echocardiography, respectively. RESULTS: After 12 weeks of protocol, no significant differences were observed in time and frequency domains measures of HRV in both groups. The ejection fraction improved non-significantly in exercise group (67.5 +/- 12.6% versus 70.4 +/- 12%) and decreased non-significantly in control group (73.6 +/- 8.4% versus 71.4 +/- 7.6%). CONCLUSION: A 12-week aerobic training program performed during hemodialysis did not modify HRV and did not significantly improve the left ventricular function.

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