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A randomised trial of a weight loss intervention for overweight and obese people diagnosed with coronary heart disease and/or type 2 diabetes
Gallagher R, Kirkness A, Zelestis E, Hollams D, Kneale C, Armari E, Bennett T, Daly J, Tofler G
Annals of Behavioral Medicine 2012 Aug;44(1):119-128
clinical trial
6/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: Yes; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

BACKGROUND: Weight reduction limits disease progression in obese people with coronary heart disease (CHD) and/or type 2 diabetes mellitus (T2DM). PURPOSE: To test a 16-week group-based weight reduction intervention combining exercise, diet and behaviour change strategies aimed to increase self-efficacy (Healthy Eating and Exercise Lifestyle Program-HEELP) on weight, body mass index (BMI), waist circumference and exercise. METHODS: Participants with CHD and/or T2DM and BMI between 27 to 39kg/m2 were randomised to HEELP (n = 83) or usual care (n = 65). RESULTS: Participants were aged a mean 63.47years (SD 8.9), male (58%) and caucasian (79%). HEELP participants lost significantly more weight, BMI and waist circumference and exercised more days/week for a longer duration/week than usual care. Clinically significant weight loss (>= 5%) was more common in HEELP than usual care. CONCLUSION: The HEELP resulted in weight loss and improved exercise behaviour in obese people with CHD and T2DM.

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