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Ventilacao nao invasiva por pressao positiva continua na via aerea (CPAP) associada ao bronchodilatador no tratamento da crise de asma broncquica (Non-invasive ventilation for continuous positive airways pressure (CPAP) assisted to the bronchodilator in the treatment of bronchial asthma crisis) [Portuguese]
de Miranda AS, Silva COS, Beppa OS, Dumascena MCP, Vieira MDD
Fisioterapia em Movimento [Physical Therapy in Movement] 2004 Apr-Jun;17(2):17-27
clinical trial
4/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

OBJECTIVE: Evaluate: (i) the bronchodilator response in patients with acute asthma crisis, when using the ventilation mode for continuous positive airway pressure (CPAP) with facial mask associated to the bronchodilator inhaler therapy; (ii) the subjective sensation of the patient tolerance in relation to the non-passive ventilation support during crisis of bronchial asthma. METHODS: 63 patients of "Emergency of Pneumonology of the Universidade Federal de Sao Paulo -- Escola Paulista de Medicina" were randomized in 3 groups for treatment, have been following: oxihemoglobine (HbO2%), heart rate, respiratory rate, expiratory peak flow (L/min). Group A (n = 21) metered-dose inhaler (MDI) attached to the facial mask for the management of the continuous positive airway pressure (CPAP); group B (n = 21) metered-dose inhaler (MDI) interpolated to the use of the facial mask for the management of the continuous positive airway pressure (CPAP); group C (n = 21) metered-dose inhaler (MDI) submitted to the conventional treatment. STATISTICAL ANALYSIS: T student test, ANOVA and percentual variation (Kruskall-Wallis) for the variables of the respiratory rate and expiratory peak flow (EPF). Significant values were considered when the p < 0.05. RESULTS: There was no statistical variation for the Heart rate and oxihemoglobine (HbO2%) among the groups A B C. The variables which differenced in the post treatment were the respiratory rate and the peak expiratory flow, with values of p < 0.01). CONCLUSION: The use of continuous positive airway pressure (CPAP) interpolated to the bronchodilator may optimize the broncho spasm reversal when compared to the conventional treatment. The use of continuous positive airway pressure (CPAP) is well accepted in group of patients.

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