BACKGROUND: Exercise training is effective for improving physical fitness and physical function in people with type 2 diabetes. However, limited research has been conducted on the optimal exercise training intensity for this population. OBJECTIVE: The primary study objective was to investigate the effects of moderateversus high-intensity exercise training on physical fitness and physical function in people with type 2 diabetes. DESIGN: This was a randomized clinical trial. SETTING: The setting was a university campus. PARTICIPANTS: Twenty-one people with type 2 diabetes were randomly allocated to receive either moderate-intensity training (MOD group) or high-intensity training (HIGH group). INTERVENTION: The MOD group performed resistance training at an intensity of 75% of the 8-repetition maximum (8-RM) and aerobic training at an intensity of 30% to 45% of the heart rate reserve (HRR). The HIGH group performed resistance training at an intensity of 100% of the 8-RM and aerobic training at an intensity of 50% to 65% of the HRR. MEASUREMENTS: Muscle strength (peak torque (Newton-meters)), exercise capacity (graded exercise test duration (minutes)), and physical function (Patient-Specific Functional Scale questionnaire) were measured at baseline and 3 months later. Acute exercise-induced changes in glucose levels were assessed immediately before exercise, immediately after exercise, and 1 hour after exercise during the first exercise training session. RESULTS: Although both groups showed improvements in physical fitness and physical function, the between-group effect sizes were not statistically significant (exercise capacity estimated marginal mean (EMM) difference 2.1, 95% confidence interval (95% CI) -0.2 to 4.5; muscle strength EMM difference 20.8, 95% CI -23.3 to 65.0; and physical function EMM difference 0.1, 95% CI -0.6 to 0.9). Mean percent changes in glucose levels measured immediately before exercise and immediately after exercise, immediately after exercise and 1 hour after exercise, and immediately before exercise and 1 hour after exercise for the MOD group were -11.4%, -5.0%, and -15.8%, respectively; those for the HIGH group were -21.5%, 7.9%, and -15.3%, respectively. LIMITATIONS: Sample size, lack of outcome assessor masking, and physical function measurement subjectivity were limitations. CONCLUSIONS: Moderate- and high-intensity exercise training, as defined in this study, may lead to similar improvements in physical fitness and physical function in people with type 2 diabetes.

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