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The effect of multimodal exercise training program in subject with type 2 diabetes mellitus
Acar S, Malkoc M, Calan M, Cimrin D, Gedik A, Bayraktar F
Turkish Journal of Endocrinology and Metabolism 2014 Sep;18(3):67-74
clinical trial
4/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

PURPOSE: The aim of our research was to investigate the effect of multimodal aerobic, resistance and flexibility exercise training program on cardiovascular disease risk factor related with exercise capacity, lipid profile, flexibility, body composition, and glycemic control in newly diagnosed type 2 diabetic patients. MATERIAL AND METHOD: Sixteen newly diagnosed type 2 diabetes patients including 6 study subjects and 10 controls were enrolled in the study. Study group attended to exercise program for a period of 12 weeks. Body composition, flexibility, aerobic capacity, lipid profile, fasting blood glucose (FBG), postprandial glucose (PPG), and hemoglobin A1c (HbA1c) levels were assessed in all participants. RESULTS: Body fat decreased, flexibility, which was assessed using the sit and reach test, and aerobic capacity increased after the exercise program, these variables showed statistically significant difference within the groups (p < 0.05). Triglyceride cholesterol and postprandial glucose levels showed statistically significantly decrease after the exercise program in all participants (p < 0.05). Only post exercise FBG and hemoglobin A1c levels showed statistically significant difference between exercise and control groups (p < 0.05). Additionally, the Borg Scale significantly positively correlated with FBG (r = 0.63, p = 0.09), PPG (r = 0.51, p = 0.039), and HbA1c (r = 0.59, p = 0.014). DISCUSSION: Twelve-week multimodal exercise training program improved the aerobic capacity and flexibility and decreased the cardiovascular disease risk related glycemic control by controlling body fat and triglycerides and by maintaining FBG and HbA1c below certain values.

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