OBJECTIVE: This study was designed to test the effect of 8-week lower body resistance training on hyperglycemia and dyslipidemia, which may be prevalent among non-elderly, non-diabetic, chronically disabled stroke patients. DESIGN: Randomized controlled study. SETTINGS: Outpatient clinics of rehabilitation centers. PARTICIPANTS: Fifty-six non-elderly, non-diabetic, chronically disabled stroke subjects were enrolled and randomly divided into the experimental group (n = 28) and control group (n = 28). INTERVENTIONS: Lower body resistance training was performed by subjects in the experimental group three times per week for eight weeks. The control group was given duration matched stretch exercise. MAIN OUTCOME MEASURES: Fasting glucose, fasting insulin, 2-hour blood glucose in OGTT, HOMA-IR, HbAc1, total triglycerides, total cholesterol, HDL cholesterol, LDL cholesterol, BMI, lower-limbs muscle strength, Fugl-Meyer motor score. RESULTS: In total, 34 (60.7%) and 38 (67.9%) subjects suffered hyperglycemia and dyslipidemia before the intervention. Fifty-one subjects finished the study, subjects (n = 26) in the experimental group showed significant improvements in fasting insulin, 2-hour blood glucose, HOMA-IR, total cholesterol, HDL cholesterol, LDL cholesterol, and muscle strength compared with control ones (n = 25) after intervention (p < 0.05). CONCLUSIONS: Resistance training may play a significant role in improving hyperglycemia and dyslipidemia, which are prominent among non-elderly, non-diabetic, chronically disabled stroke patients.

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