OBJECTIVE: To investigate the effect of an exercise training program on lipid profile in correlation with DHEA level and body weight and body composition in type 2 diabetic men. DESIGN: Longitudinal, controlled clinical intervention study with exercise training consisting of an 8 week supervised program of aerobic exercise (75% VO2peak, 45 min), twice a week and intermittent exercise, once a week, on a bicycle ergometer. SUBJECTS: Sixteen men (age 45.4 +/- 7.2 y (mean +/- SD), HbA1c 8.15 +/- 1.7%, body mass index (BMI) 29.6 +/- 4.6 kg/m2) were randomly divided into two groups: trained group (n = 8) and control group (n = 8). MEASUREMENTS: Lipid, apo- and lipo-protein and DHEA concentrations. Cross-sectional areas of subcutaneous and visceral adipose tissue and mid-thigh muscle by magnetic resonance imaging. RESULTS: Training decreased visceral (153.25 +/- 38.55 versus 84.20 +/- 21.30 cm2, p < 0.001), subcutaneous (241.55 +/- 49.55 versus 198.00 +/- 39.99 cm2, p < 0.001) adipose tissue area and triglyceride levels (2.59 +/- 1.90 versus 1.79 +/- 1.08 nmol/l, p < 0.05) and increased mid-thigh muscle cross-sectional area (148.30 +/- 36.10 versus 184.35 +/- 35.85 cm2, p < 0.001), and DHEA levels (11.00 +/- 3.10 versus 14.25 +/- 4.10 nmol/l, p < 0.05) with no modification in body weight. Changes in triglycerides were negatively correlated with changes in DHEA (r = -0.81, p = 0.03). This correlation was independent of changes in abdominal fat distribution. CONCLUSION: Training decreases abdominal fat depots, improves muscular mass and affects favourably triglyceride and DHEA levels. Changes in triglycerides and DHEA were inversely related.

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