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| Effect of very early mobilisation on functional status in patients with acute stroke: a single-blind, randomized controlled trail [with consumer summary] |
| Chippala P, Sharma R |
| Clinical Rehabilitation 2016 Jul;30(7):669-675 |
| clinical trial |
| 7/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: Yes; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: Yes; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed* |
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OBJECTIVE: To evaluate the effect of very early mobilisation on functional status following acute stroke. DESIGN: Single blind, randomized controlled trial. SETTING: University hospital. SUBJECTS: Eighty-six patients with acute stroke (42 men and 38 women) aged 30 to 80 years were randomized to an Intervention group and a standard care group. INTERVENTIONS: All participants received 45 minutes standard care once a day for seven days. In addition, the intervention group (n = 43) performed very early mobilisation consisting of early and frequent out of bed activities which started within 24 hours of stroke onset for 5 to 30 minutes at least twice a day, for seven days. OUTCOME MEASURES: Functional status was measured with Barthel ADL Index on admission, discharge and three months follow up. RESULTS: Intervention group showed a significant improvement in Barthel Index change scores (discharge minus admission) (median 35, IQR 30 to 38.75 versus median 17.50, IQR 10 to 30) than the standard care group. Intervention group showed a significant improvement in Barthel Index change scores (three month follow up minus admission) (median 42.50, IQR 35 to 55) versus (median 30, IQR 20 to 35) than the standard care group. The Intervention group reported statistically significant improvement in functional status at discharge (p < 0.001) and at three months follow up (p < 0.001) compared with the standard care group. CONCLUSIONS: The results indicate that very early mobilisation in addition to the standard care may be effective in improving the functional status following acute stroke.
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