OBJECTIVE: We investigated the training effects of interlimb force coupling training on paretic upper extremity outcomes in patients with chronic stroke and analyzed the relationship between motor recovery of the paretic hand, arm and functional performances on paretic upper limb. DESIGN: A randomized controlled trial with outcome assessment at baseline and after 4 weeks of intervention. SETTING: Taipei Veterans General Hospital, National Yang-Ming University. PARTICIPANTS: Thirty-three subjects with chronic stroke were recruited and randomly assigned to training (n = 16) and control groups (n = 17). INTERVENTIONS: The computer-aided interlimb force coupling training task with visual feedback included different grip force generation methods on both hands. MAIN OUTCOME MEASURES: The Barthel Index (BI), the upper extremity motor control Fugl-Meyer Assessment (FMA-UE), the Motor Assessment Score (MAS), and the Wolf Motor Function Test (WMFT). All assessments were executed by a blinded evaluator, and data management and statistical analysis were also conducted by a blinded researcher. RESULTS: The training group demonstrated greater improvement on the FMA-UE (p < 0.001), WMFT (p < 0.001), MAS (p = 0.004) and BI (p = 0.037) than the control group after 4 weeks of intervention. In addition, a moderate correlation was found between the improvement of scores for hand scales of the FMA and other portions of the FMA UE (r = 0.528, p = 0.018) or MAS (r = 0.596, p = 0.015) in the training group. CONCLUSION: Computer-aided interlimb force coupling training improves the motor recovery of a paretic hand, and facilitates motor control and enhances functional performance in the paretic upper extremity of people with chronic stroke. TRIAL REGISTRATION: ClinicalTrials.gov NCT02247674.

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