BACKGROUND AND AIMS: The main long-term problems of chronic diabetes are cardiovascular complications classified as micro/macro-vascular complications. The consequences for patients include cardiovascular diseases, nephropathy, retinopathy, and so on. Due to the effect of exercise on tissue blood flow distribution and the different nature of the two types of resistance and aerobic exercises, this study aimed to compare the effect of aerobic and resistance trainings on angiostatin level of men with type 2 diabetes. METHODS: A total of 26 men with type 2 diabetes (mean age 64.56 +/- 11.3 years, mean weight 68.50 +/- 5.42 kg, mean height 150 +/- 43.162 cm and 10-year history of diabetes) referred to Kerman Diabetes Center were purposefully selected and randomly divided into two groups of aerobic and resistance trainings. After being familiarized with the research protocol, subjects did resistance exercises based on a percentage of the maximal strength (1 RM) and the endurance exercise with the intensity of percentage of maximum consumed oxygen three sessions in week (40 to 60 minutes each session) and for 12 weeks. Blood samples before and 24 hours after the last training session were collected. For comparison within the groups, independent t-test and for comparison between groups, repeated measure two-way ANOVA were used. RESULTS: Serum anigiostatin level and VEGFR showed no significant difference between the two groups (p = 0.116, p = 0.218 respectively), but groups showed significant increase in serum angiostatin level and VEGFR after the intervention (p < 0.05). CONCLUSION: The results showed that twelve weeks of resistance and aerobic exercises can improve of men with type 2 diabetes and increases their anigiostatin level but non significantly.

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