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Combined exercise training improves glycemic control in adult with cystic fibrosis
Beaudoin N, Bouvet GF, Coriati A, Rabasa-Lhoret R, Berthiaume Y
Medicine and Science in Sports and Exercise 2017 Feb;49(2):231-237
clinical trial
4/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

PURPOSE: Glucose abnormality and diabetes are the most common comorbidities in cystic fibrosis (CF). Combined (aerobic and resistance) exercise program in type 2 diabetes patients demonstrated an improvement of glycemic control. The aim of the study was to determine if a combined exercise program is beneficial to improve plasma glucose at 2-h of the oral glucose tolerance test (OGTT) in CF. METHOD: 18 adult with CF with glucose abnormality were recruited (ClinicalTrials.gov NTC02127957) and 17 were randomly assigned to a control or exercise group for 12 weeks. VO2max, OGTT, muscular endurance and strength, and quality of life were measured pre and post intervention. RESULTS: 14 participants completed the protocol. Patients in the exercise group improved significantly their 2-h plasma glucose values (-2.34 +/- 1.26 mmol/L; p < 0.007; CI 99.22%) and presented a reduction of 17.2% (p < 0.05) in total glucose excursion. No significant change for other parameters was observed. CONCLUSION: A combined exercise program improves glycemic control in CF.

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