OBJECTIVES: To compare 12 weeks of exercise training at two intensities on oxidative stress, antioxidants and inflammatory biomarkers in patients with type 2 diabetes (T2D). DESIGN: Randomized trial. METHODS: Thirty-six participants with T2D were randomized to complete either 12 weeks of treadmill based high-intensity interval training (HIIT) or moderate-intensity continuous training (MICT), followed by 40 weeks of home-based training at the same intensities. Plasma inflammation, oxidative stress and antioxidant biomarkers (total F2-isoprostanes, protein carbonyls, total antioxidant capacity, glutathione peroxidase activity, interleukin-10, interleukin-6, interleukin-8 and TNF-alpha) were measured at baseline, 12-weeks and 1-year. RESULTS: There were no significant changes (p > 0.05) in oxidative stress and inflammation biomarkers from baseline to 12-weeks in either intervention. A decrease in total antioxidant capacity in the MICT group from baseline to 1-year by 0.05. mmol/L (p = 0.05) was observed. There was a significant difference (p < 0.05) when groups were separated by sex with females in the MICT group having a 22.1% (p < 0.05) decrease in protein carbonyls from baseline to 1-year. CONCLUSIONS: HIIT and MICT had no acute effect on oxidative stress and inflammatory biomarkers in patients with T2D.

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