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Effects of progressive resistance training on cardiovascular autonomic regulation in patients with Parkinson's disease: a randomized controlled trial
Kanegusuku H, Silva-Batista C, Pecanha T, Nieuwboer A, Silva ND Jr, Costa LAR, de Mello MT, Piemonte MEP, Ugrinowitsch C, Forjaz CLM
Archives of Physical Medicine and Rehabilitation 2017 Nov;98(11):2134-2141
clinical trial
5/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

OBJECTIVE: To evaluate the effects of a progressive resistance training (RT) on cardiac autonomic modulation and on cardiovascular responses to autonomic stress tests in patients with Parkinson disease (PD). DESIGN: Randomized clinical trial. SETTING: The Brazilian Parkinson Association. PARTICIPANTS: 30 patients with PD (modified Hoehn and Yahr stages 2 to 3) were randomly divided into 2 groups: a progressive RT group (PDT) and a control group (PDC). In addition, a group of paired healthy control subjects without PD (HC) was evaluated. INTERVENTIONS: PDT group performed 5 resistance exercises, 2 to 4 sets, 12 to 6 repetitions maximum per set. PDC group maintained their usual lifestyle. MAIN OUTCOME MEASURES: PDT and PDC groups were evaluated before and after 12-weeks. HC group was evaluated once. Autonomic function was assessed by spectral analysis of heart rate (HR) variability and cardiovascular responses to autonomic stress tests (deep breathing, Valsalva maneuver and orthostatic stress). RESULTS: Compared with baseline, normalized low-frequency component of HR variability decreased significantly after 12 weeks in the PDT group only (PDT 61 +/- 17 versus 47 +/- 20 nu and PDC 60 +/- 14 versus 63 +/- 10 nu, interaction p < 0.05). Similar result was observed for systolic blood pressure fall during orthostatic stress that also reduced only in the PDT group (PDT -14 +/- 11 versus -6 +/- 10 mmHg and PDC -12 +/- 10 versus -11 +/- 10 mmHg, interaction p < 0.05). In addition, after 12 weeks, these parameters in the PDT achieved values similar to the HC group. CONCLUSION: In patients with PD, progressive RT improved cardiovascular autonomic dysfunction.

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