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Comparison of salbutamol given by intermittent positive-pressure breathing and pressure-packed aerosol in chronic asthma
Anderson PB, Goude A, Peake MD
Thorax 1982 Aug;37(8):612-616
clinical trial
4/10 [Eligibility criteria: No; Random allocation: Yes; Concealed allocation: No; Baseline comparability: No; Blind subjects: Yes; Blind therapists: No; Blind assessors: No; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: No; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

A double-blind crossover study was performed to compare 4.8 mg salbutamol given by pressure-packed aerosol and intermittent positive-pressure breathing nebulization in chronic asthmatic patients. The two delivery techniques produced similar changes in respiratory function and pulse rates. Given equal effect, a high-dose pressure-packed aerosol would have advantages in cost and convenience over nebulization techniques.
Reproduced with permission from the BMJ Publishing Group.

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