BACKGROUND: To explore the effect of comprehensive rehabilitation training (CRT) on cognitive impairment, anxiety, and depression in poststroke patients. METHODS: 168 poststroke patients were consecutively recruited in this randomized controlled study. Patients were randomly assigned to CRT group (CRT plus conventional treatment) and control group (conventional treatment) as 1:1 ratio. The specific interventions of CRT included patient and family member education, cognitive training, rehabilitation training, and regular check. RESULTS: Both montreal cognitive assessment score change (month12 (M12) minus baseline; p = 0.001) and minimum mental state examination score change (M12 minus baseline) were higher in CRT group than that in control group (p = 0.004), and the percentage of cognitive impairment by Montreal Cognitive Assessment Score <= 26 was lower (p = 0.003) in CRT group compared to control group at month 12. Anxiety assessments were performed by hospital anxiety and depression scale (HADS) and Zung self-rating anxiety scale (SAS). The HADS anxiety score change (M12 minus baseline; p = 0.002) and the SAS score change (M12 minus baseline; p = 0.006) were decreased in CRT group compared to control group. Lower occurrence rate of anxiety assessed by SAS was observed in CRT group compared to control group (p = 0.033). Depression assessments were performed by HADS and Zung self-rating depression scale (SDS). HADS depression score change (M12 minus baseline; p < 0.001) and the SDS score change (M12 minus baseline; p = 0.002) were reduced in CRT group compared to control group. Decreased occurrence rate of depression assessed by SDS was found in CRT group compared to control group (p = 0.022). CONCLUSIONS: CRT contributes to the recovery of cognitive impairment, and decreases anxiety and depression in poststroke patients.
Copyright by WB Saunders Company.

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