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Effectiveness and feasibility of acupuncture for knee osteoarthritis: a pilot randomized controlled trial [with consumer summary]
Lin L-L, Li Y-T, Tu J-F, Yang J-W, Sun N, Zhang S, Wang T-Q, Shi G-X, Du Y, Zhao J-J, Xiong D-C, Hou H-K, Liu C-Z
Clinical Rehabilitation 2018 Dec;32(12):1666-1675
clinical trial
8/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: Yes; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: Yes; Adequate follow-up: Yes; Intention-to-treat analysis: Yes; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

OBJECTIVE: To evaluate the effectiveness of acupuncture for pain relief and function improvement in patients with knee osteoarthritis and to determine the feasibility of an eight-week acupuncture intervention. DESIGN: Pilot randomized controlled trial. SETTING: Three teaching hospitals in China. SUBJECTS: Patients with knee osteoarthritis (Kellgren grade II or III). INTERVENTIONS: Patients were randomly assigned to an eight-week (three sessions per week) intervention of either traditional Chinese acupuncture or sham acupuncture. MAIN MEASURES: The primary outcome was response rate-the proportion of patients achieving score 36% decrease in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain and function at week 8 compared with baseline. Secondary outcomes included pain, function and quality of life. RESULTS: Of 42 patients randomized, 36 (85.7%) completed the study. There was no significant difference in response rate between the traditional Chinese acupuncture and control groups: 61.9% (13 of 21) versus 42.9% (9 of 21) achieved score 36% decrease in WOMAC pain and function at week 8 (p = 0.217). The sum of WOMAC pain and function scores at week 8 was 11.6 (9.1) in the traditional Chinese acupuncture group compared with 16.3 (10.9) in the control group (p = 0.183). There was no significant difference between groups. Three adverse events were recorded and were classified as mild. CONCLUSION: It showed that three sessions per week acupuncture intervention of knee osteoarthritis was feasible and safe. No difference was observed between groups due to small sample size. Larger (sample size 296) randomized controlled trials of this intervention appear justified.

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