BACKGROUND/AIMS: Fatty liver is a clinical and pathologic condition in individuals with type 2 diabetes (T2D). The purpose of this study is to examine the effects of different exercise modalities on non-alcoholic fatty liver indices (fatty liver index (FLI), lipid accumulation product (LAP), hepatic steatosis index (HSI), and Framingham Steatosis Index (FSI)) in women with T2D. METHODS: Fifty-two women with T2D and a mean age of 55.07 +/- 5.92 yrs, body mass index (BMI) 28.94 +/- 4.09 kg/m2, and hemoglobin A1c (HbA1c) 9.41 +/- 0.82% were randomized to a sprint interval training (SIT) (n = 17), combined aerobic and resistance (A+R) training (n = 17), or control group (n = 18) for 10 weeks. Two-way repeated analysis of variance (ANOVA) was used to find differences between groups and the effects of time and time x group interactions after 10 weeks on non-alcoholic fatty liver indices. After this, ANOVA models were constructed to determine the effects of group allocation and change in non-alcoholic fatty liver indices. RESULTS: There were significant time interactions for FLI (p < 0.001), HSI (p < 0.001), and LAP (p < 0.001). Also, there were significant time x group interactions for fasting blood glucose (p = 0.034), and HbA1c (p = 0.006). CONCLUSIONS: Results highlight that exercise training, independent of mode of training, is an effective strategy to improve some indices related to hepatic steatosis and blood glucose profiles in women with T2D.

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