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Effects of blood flow restriction training with protein supplementation on muscle mass and strength in older men [with consumer summary]
Centner C, Zdzieblik D, Roberts L, Gollhofer A, Konig D
Journal of Sports Science & Medicine 2019 Sep;18(3):471-478
clinical trial
8/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: Yes; Baseline comparability: Yes; Blind subjects: No; Blind therapists: Yes; Blind assessors: Yes; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

Blood flow restriction (BFR) training has been shown to induce favorable changes in muscle mass and strength with a considerably low training load (20 to 30% 1RM). However, it has never been evaluated if an additional post-exercise protein supplementation enhances the effects of this training regimen. Thirty healthy older men (60.1 +/- 7.6 years) were enrolled in the 8-week intervention and randomly allocated to one of the following groups: low-load BFR training with protein (collagen hydrolysate) supplementation (BFR-CH), low-load BFR training with placebo (BFR-PLA), or a control group without training, but with protein supplementation (CON). Muscle cross-sectional area (CSA), muscle strength, circulating reactive oxygen species and IGF-1 were measured before and after the intervention. Muscle CSA increased in both BFR-CH and BFR-PLA groups by 6.7 +/- 3.2% (p < 0.001) and 5.7 +/- 2.7% (p < 0.001) respectively. No significant changes were observed in the CON group (1.1 +/- 1.7%, p = 0.124). Evaluation of isometric strength (p = 0.247), insulin-like growth factor 1 (p = 0.705) and the production of reactive oxygen species (pt1 = 0.229; pt2 = 0.741) revealed no significant interaction effect but a significant long-term time effect (p < 0.001). Our results demonstrate that BFR training is an effective alternative for increasing muscle CSA in older men. Although there was a trend towards greater muscle mass adaptations in the BFR-CH group, these findings showed no statistical significance. Further research with larger sample sizes is needed to confirm these results.

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