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Interval exercise lowers circulating CD105 extracellular vesicles in prediabetes
Eichner NZM, Gilbertson NM, Heiston EM, Musante L, la Salvia S, Weltman A, Erdbrugger U, Malin SK
Medicine and Science in Sports and Exercise 2020 Mar;52(3):729-735
clinical trial
4/10 [Eligibility criteria: No; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

BACKGROUND: Extracellular vesicles (EVs) are purported to mediate type 2 diabetes (T2D) and cardiovascular disease (CVD) risk and development. Physical activity and a balanced diet reduce disease risk, but no study has tested the hypothesis that short-term interval (INT) training would reduce EVs compared with continuous (CONT) exercise in adults with prediabetes. METHODS: Eighteen obese adults (age 63.8 +/- 1.5 yrs BMI 31.0 +/- 1.3 kg/m) were screened for prediabetes using American Diabetes Association criteria (75g OGTT). Subjects were randomized to INT (n = 10, alternating 3 min intervals at 90% and 50% HRpeak, respectively) or CONT (n = 8, 70% HRpeak) training for 12 supervised sessions over 13 d for 60 min/d. Cardiorespiratory fitness (VO2peak), weight (kg), as well as ad-libitum dietary intake were assessed and arterial stiffness (augmentation index via applanation tonometry; AIx) was calculated using total AUC during a 75g OGTT performed 24 hr following the last exercise bout. Total EVs, platelet EVs (CD31/CD41), endothelial EVs (CD105; CD31/CD41), platelet endothelial cell adhesion molecule (PECAM) (CD31) and leukocyte EVs (CD45; CD45/CD41) were analyzed via imaging flow cytometry pre-/post- intervention. RESULTS: INT exercise increased VO2peak (p = 0.04) compared to CONT training. While training had no effect on platelet or leukocyte EVs, INT decreased Annexin V- endothelial EV CD105 compared with CONT (p = 0.04). However, after accounting for dietary sugar intake the intensity effect was lost (p = 0.18). Increased ad-libitum dietary sugar intake following training was linked to elevated AV+ CD105 (r = 0.49, p = 0.06) and AV-CD45 (r = 0.59, p = 0.01). Nonetheless, increased VO2peak correlated with decreased AV+ CD105 (r = -0.60, p = 0.01). CONCLUSION: Interval exercise training decreases endothelial derived EVs in adults with prediabetes. Although increased sugar consumption may alter EVs following a short-term exercise intervention, fitness modifies EV count.

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