INTRODUCTION: Regular exercise training has been shown to be a useful option to treat and prevent type 2 diabetes. Correspondingly, the purpose of this study was to investigate effects of 12 weeks of combined aerobic-resistance exercise training on levels of chemerin, omentin and insulin resistance in men with type 2 diabetes. MATERIAL(S) AND METHOD(S): In this clinical trial research, 20 male patients with type 2 diabetes were randomly divided into two groups combined aerobic-resistance training (n = 10) and control (n = 10). Subjects in training group performed 12 weeks aerobic-resistance training, 3 weekly training sessions with given intensity (aerobic: intensity of 60 to 70% maximum heart rate resistance: intensity 60 to 70% repetition maximum). Blood sampling was taken measurements of for chemerin, omentin resistance, fasting glucose and insulin resistance in the beginning and after 12 training protocol weeks were conducted. RESULT(S): After 12 weeks, in the combined training group chemerin (p = 0.01), resistance insulin (p = 0.01) and fasting glucose (p = 0.001) decreased significantly and VO2max increased significantly (p = 0.001) than the control group. Significant change was not observed at the levels of omentin (p = 0.37). CONCLUSION(S): 12 weeks of aerobic-resistance training in men with type 2 diabetes decreased the levels of chemerin, insulin resistance and also fasting glucose, but did not affect the level of omentin.

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