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(Meta-analysis of the effect of aerobic exercise on mild cognitive impairment in the elderly) [Chinese - simplified characters]
Liu D, Li R, Zhang M, Chen Y, Zhang H
Chinese Journal of Tissue Engineering Research 2019 Dec 25;23(35):5727-5731
systematic review

BACKGROUND: Preliminary study has shown that exercise can improve the cognitive function in senile dementia and patients with mild cognitive impairment. OBJECTIVE(S): To understand the effect of aerobic exercise on mild cognitive impairment in elderly people in China by meta-analysis. METHOD(S): The search strategies and inclusion and exclusion criteria were developed, and CNKI, CBMdisc, WanFang, VIP, PubMed, EBSCOhost and Cochrane library databases were searched to retrieve the randomized controlled trials concerning aerobic exercise in the elderly patients with mild cognitive impairment. Risk assessment of Cochrane bias was performed, valid information was selected and input, and meta-analysis was performed on RevMan 5.3 software. RESULTS AND CONCLUSION(S): Finally, nine articles were obtained, all of which were randomized controlled studies. Meta-analysis results showed that the mini-mental state examination score in the trial group was higher than that in the control group after aerobic exercise intervention (MD 1.51, 95%CI 0.54 to 2.48, p < 0.01). The Montreal Cognitive Assessment score in the trial group was higher than that in the control group (MD 2.90, 95%CI 1.92 to 3.88, p < 0.000 01). After 3 months of aerobic exercise intervention, the cognitive score in the trial group was higher than that in the control group (SMD 0.77, 95%CI 0.33 to 1.20, p = 0.000 6). After 6 months of aerobic exercise intervention, the cognitive score in the trial group was higher than that in the control group (SMD 0.73, 95%CI 0.19 to 1.28, p = 0.008). After several months of aerobic exercise intervention, the cognitive score in the trial group was higher than that in the control group (SMD 0.89, 95%CI 0.60 to 1.18, p < 0.00001). In summary, long-term exercise can improve the cognitive function in the elderly, and this method is safe and feasible, and is easy to carry out in the elderly.

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