BACKGROUND: Resistance exercise has been shown to be beneficial for improving glycolipid metabolism in patients with type 2 diabetes mellitus. But the mode, intensity and frequency of resistance exercise, as well as the effective combination with different other exercises need to be further explored and confirmed. OBJECTIVE(S): To evaluate the effect of resistance exercise on glucose and lipid metabolism disorder in type 2 diabetes mellitus. METHOD(S): Databases of PubMed, FMRS, Embase, the Cochrane Library, and Wanfang were searched to collect the randomized controlled trials (blank control, aerobic exercise and resistance exercise groups) concerning resistance exercise for treating type 2 diabetes mellitus. The retrieval time was set from inception to December 2018, and the references in the included articles were retroactively searched. According to the inclusion and exclusion criteria, two researchers screened the literature, extracted data, and assessed the quality. Meta-analysis was performed on RevMan 5.3 software. RESULTS AND CONCLUSION(S): (1) Eleven randomized controlled trials were included. The selective report and other risk bias were unclear, but the overall literature quality was on the above-average. (2) Meta-analysis results showed that the resistance exercise group significantly improved fasting blood glucose (SMD 0.84, 95%CI 0.39 to 1.29, p = 0.0002), glycosylated hemoglobin (SMD 0.44, 95%CI 0.06 to 0.81, p = 0.02), triglyceride (SMD 0.55, 95%CI 0.07 to 1.04, p = 0.02), high-density lipoprotein cholesterol (SMD -0.33, 95%CI -0.53 to -0.13, p = 0.001), low-density lipoprotein cholesterol (SMD 0.49,95%CI -0.03 to 1.01, p = 0.06). (3) The resistance exercise group was superior to the blank control group and showed no significant difference compared with the aerobic exercise group. (4) These results indicate that resistance exercise contribute to improving glucose and lipid metabolism in patients with type 2 diabetes mellitus and can be an important part of exercise therapy for diabetes mellitus.

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