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Hypoxic exercise training to improve exercise capacity in obese individuals
Chacaroun S, Borowik A, Vega-Escamilla YGI, Doutreleau S, Wuyam B, Belaidi E, Tamisier R, Pepin JL, Flore P, Verges S
Medicine and Science in Sports and Exercise 2020 Aug;52(8):1641-1649
clinical trial
6/10 [Eligibility criteria: No; Random allocation: Yes; Concealed allocation: Yes; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

INTRODUCTION: Combining exercise training with hypoxic exposure has been recently proposed as a new therapeutic strategy to improve health status of obese individuals. Whether hypoxic exercise training (HET) provides greater benefits regarding body composition and cardiometabolic parameters than normoxic exercise training (NET) remains, however, unclear. We hypothesized that HET would induce greater improvement in exercise capacity and health status than NET in overweight and obese individuals. METHODS: Twenty-three subjects were randomized into 8-wk HET (11 men and 1 woman; age 52 +/- 12 yr; body mass index 31.2 +/- 2.4 kg/m2) or NET (eight men and three women; age 56 +/- 11 yr; body mass index 31.8 +/- 3.2 kg/m2) programs (three sessions per week; constant-load cycling at 75% of maximal heart rate; target arterial oxygen saturation for HET 80%, FiO2 approxiamtely 0.13, ie, approximately 3,700 m ASL). Before and after the training programs, the following evaluations were performed: incremental maximal and submaximal cycling tests, measurements of pulse-wave velocity, endothelial function, fasting glucose, insulin and lipid profile, blood NO metabolites and oxidative stress, and determination of body composition by magnetic resonance imaging. RESULTS: Peak oxygen consumption and maximal power output increased significantly after HET only (peak oxygen consumption HET +10% +/- 11% versus NET +1% +/- 10% and maximal power output HET +11% +/- 7% versus NET +3% +/- 10%, p < 0.05). Submaximal exercise responses improved similarly after HET and NET. Except diastolic blood pressure which decreased significantly after both HET and NET, no change in vascular function, metabolic status and body composition was observed after training. Hypoxic exercise training only increased nitrite and reduced superoxide dismutase concentrations. CONCLUSIONS: Combining exercise training and hypoxic exposure may provide some additional benefits to standard NET for obese individual health status.

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