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A 12-week exercise program improves functional status in post-menopausal osteoporotic women: randomized controlled study [with consumer summary]
Filipovic TN, Lazovic MP, Backovic AN, Filipovic AN, Ignjatovic AM, Dimitrijevic SS, Gopcevic KR
European Journal of Physical and Rehabilitation Medicine 2021 Feb;57(1):120-130
clinical trial
6/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: Yes; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

BACKGROUND: Beside the importance of implementing physical activity in treatment of patients with osteoporosis, the multicomponent exercise program and assessment of its functional outcomes performed by five performance-based measures, have not been explored yet. AIM: The present study evaluated the effect of the 12 weeks exercise program on functional outcomes of postmenopausal patients with densitometric diagnosed osteoporosis. DESIGN: The study was designed as randomised control study. SETTING: Female outpatients with diagnosed postmenopausal osteoporosis were included in the study. POPULATION: Women from urban area were presented. METHODS: Patients were randomized in two groups: "exercise group" (EG) and "control group" (CG). Patients in the exercise group (n = 47) participated in a 12 weeks exercise program, which consisted of resistance training, balance exercise and aerobic exercise, while patients from control group (n = 49) had not participated in any exercise program during the intervention period. Functional outcomes determined by "Time Up and Go" test (TUG), "Sit To Stand" test (STS) and "One Leg Stance Test" (OLST) were evaluated at baseline and 4 and 12 weeks after treatment, while "Fall Efficacy Scale" (FES-I) and "knowledge about osteoporosis questionnaire" (OKAT-S) were assessed at baseline andafter 12 weeks, respectively. RESULTS: There were noticed statistically significant improvement in all observed measurements in EG after 4 and 12 weeks, respectively. Comparison between groups showed statistically significant difference in EG compared to CG in all functional outcomes in observed periods (p < 0.001 for all). OLST significantly changed only in EG, not in CG, in both experimental periods. After 4 weeks, in CG there were no statistically significant changes in any of the monitored parameters, while after 12 weeks improvements were detected with TUG, STS, FES-I and OKAT-S. CONCLUSIONS: 12 weeks exercise program, as an effective, inexpensive and easily performed method, improved functional status in postmenopausal osteoporotic women.

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