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Effect of the school-based asthma care for teens (SB-ACT) program on asthma morbidity: a 3-arm randomized controlled trial
Halterman JS, Riekert KA, Fagnano M, Tremblay PJ, Blaakman SW, Tajon R, Wang H, Borrelli B
The Journal of Asthma 2022;59(3):494-506
clinical trial
6/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: Yes; Intention-to-treat analysis: Yes; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

Urban adolescents with asthma often have inadequate preventive care. We tested the effectiveness of the school-based asthma care for teens (SB-ACT) program on asthma morbidity and preventive medication adherence. METHODS: SUBJECTS/SETTING: 12 to 16yr olds with persistent asthma in Rochester, NY schools. DESIGN: 3-group randomized trial (2014 to 2019). SB-ACT intervention -- two core components: (1) directly observed therapy (DOT) of preventive asthma medications, provided in school for at least 6 to 8 weeks for the teen to learn proper technique and experience the benefits of daily preventive therapy; (2) 4 to 6 weeks later, 3 sessions of motivational interviewing (MI) to discuss potential benefits from DOT and enhance motivation to take medication independently. We included 2 comparison groups: (1) DOT-only for 6 to 8 wks, and (2) asthma education (AE) attention control. Masked follow-up assessments were conducted at 3, 5, and 7 mos. OUTCOMES: Mean number of symptom-free days (SFDs)/2 weeks and medication adherence. ANALYSES: Modified intention-to-treat repeated measures analysis. RESULTS: We enrolled 430 teens (56% Black, 32% Hispanic, 85% Medicaid). There were no group differences at baseline. We found no difference in SFDs at any follow-up timepoint. More teens in the SB-ACT and DOT-only groups reported having a preventive asthma medication at each follow-up (p < 0.001), and almost daily adherence at 3 and 5-months (p < 0.001, p = 0.003) compared to AE. By 7 months there were no significant differences between groups in adherence (p = 0.49). CONCLUSION: SB-ACT improved preventive medication availability and short-term adherence but did not impact asthma symptoms. Further work is needed to create developmentally appropriate and effective interventions for this group.

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