OBJECTIVE: To evaluate the effects of Transcutaneous Electric Nerve Stimulation (TENS) on pain, function, walking ability and stiffness in people with Knee osteoarthritis (KOA). DESIGN: Systematic review and meta-analysis of randomized controlled trials. METHODS: We searched Medline, Embase, PubMed, Cochrane Central Register of Controlled Trials, Physiotherapy Evidence Database (PEDro), ClinicalTrials.gov and Web of Science (last search November 2021) for randomized controlled trials. The Cochrane Risk of Bias Tool was used for the included studies, and Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) was used to interpret the certainty of results. Standardized Mean Differences (SMDs) and 95% confidence interval (CI) were calculated for meta-analysis. RESULTS: Twenty-nine studies were found (1,398 people, age range 54 to 85, 74% are female) and fourteen were included in this review. Intervention duration was divided as short term (immediately after intervention), medium term (< four weeks) and long term (>= four weeks). Active TENS showed greater improvement in Visual Analogue Scale (VAS) than sham TENS. Combining TENS with other interventions produced superior outcomes compared with other interventions for VAS in all the terms. In the meanwhile, TENS combined with other interventions was superior to other interventions for the pain subgroup of Western Ontario and McMaster Universities Arthritis Index in the medium term and long term. TENS combined with other interventions was superior to other interventions for function in the medium term and long term. CONCLUSION: TENS could significantly relieve pain, decrease dysfunction and improve walking ability in people with KOA, but it is not effective for stiffness.

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