OBJECTIVE: To determine whether interrupting sitting with brief bouts of simple resistance activities (SRAs) at different frequencies improves postprandial glucose, insulin, and triglycerides in adults with medication-controlled type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: Participants (n = 23, 10 of whom were female, with mean +/- SD age 62 +/- 8 years and BMI 32.7 +/- 3.5 kg/m) completed a three-armed randomized crossover trial (6- to 14-day washout): sitting uninterrupted for 7 h (SIT), sitting with 3-min SRAs (half squats, calf raises, gluteal contractions, and knee raises) every 30 min (SRA3), and sitting with 6-min SRAs every 60 min (SRA6). Net incremental areas under the curve (iAUCnet) for glucose, insulin, and triglycerides were compared between conditions. RESULTS: Glucose and insulin 7-h iAUCnet were attenuated significantly during SRA6 (glucose 17.0 mmol/h/L, 95% CI 12.5 to 21.4; insulin 1,229 pmol/h/L, 95% CI 982 to 1,538) in comparison with SIT (glucose 21.4 mmol/h/L, 95% CI 16.9 to 25.8; insulin 1,411 pmol/h/L, 95% CI 1,128 to 1,767; p < 0.05) and in comparison with SRA3 (for glucose only) (22.1 mmol/h/L, 95% CI 17.7 to 26.6; p = 0.01) No significant differences in glucose or insulin iAUCnet were observed in comparison of SRA3 and SIT. There was no statistically significant effect of condition on triglyceride iAUCnet. CONCLUSIONS: In adults with medication-controlled T2D, interrupting prolonged sitting with 6-min SRAs every 60 min reduced postprandial glucose and insulin responses. Other frequencies of interruptions and potential longer-term benefits require examination to clarify clinical relevance.
Copyright American Diabetes Association. Reprinted with permission from The American Diabetes Association.

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