OBJECTIVE: The aim was to investigate the effectiveness of Kinesio Taping for lymphedema following head and neck cancer therapy and its effect on patient compliance and quality of life. METHODS: A total of 66 patients with lymphedema following head and neck cancer therapy were randomly allocated to the therapeutic Kinesio taping group (n = 33) and the sham Kinesio Taping group (n = 33). All participants received manual lymphatic drainage, Kinesio Taping, and home exercises for the first four weeks, and only home exercises for the second four weeks. The tape measurements, a scale of external lymphedema, a scale of the internal lymphedema, and quality of life were evaluated in both groups. The perceived discomfort consisting of limitation of daily living activities, pain, tightness, stiffness, and heaviness were also recorded. RESULTS: When the group x time effect was evaluated, it was observed that external lymphedema was significantly reduced in both groups according to neck and face composite measurements (p < 0.001). However, in these measurements, a significant difference was found between the groups in favor of the KT group (p = 0.001, p = 0.032, respectively). At the end of the study, there was no significant difference in terms of internal lymphedema in both groups (p = 0.860). The quality of life parameters such as global health status and swallowing were significantly better in the Kinesio taping group (p < 0.001). There was no significant difference in the parameters of perceived discomfort between the two groups (p = 0.282, p = 0.225, p = 0.090, p = 0.155, p = 0.183, respectively). CONCLUSION: Kinesio Taping is effective in tape measurements and positively affects the quality of life in lymphedema following head and neck cancer therapy.

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