The purpose of the study was to compare the effectiveness of physiotherapist-supervised and home-based exercises after platelet-rich-plasma (PRP) injection in knee osteoarthritis (OA). Thirty women (mean age 57.83 +/- 7.26 years; mean weight 72.13 +/- 15.54 kg; mean height 158.40 +/- 4.49 cm; mean body mass index = 28.75 +/- 6.18 kg/m2) were included. Patients randomized either supervised or home-basedexercise-group after PRP. Both groups performed 6-week (3 times/week) exercise. Pain, hip and knee muscle strength, and knee functions were assessed before and after exercise. The median improvement in the pain from baseline to 6th week was 3.80 (2.85 to 5.55) point in-supervised-exercise-group while it was 0.60 (-0.10 to 2.55) point in home-based-exercise-group (p = 0.002). The median improvement in knee function was 22.91 (13.02 to 30.20) in supervised-exercise-group overtime (p < 0.001). There was no improvement in knee function following home-based exercises (p = 1.000). The supervised-exercise-group revealed a significant improvement in hip (median difference 32.00 (8.30 to 88.95), p = 0.011); quadriceps (median difference 32.10 (21.65 to 60.05), p = 0.001) and hamstring (median difference 27.90 (7.95 to 37.65), p = 0.022) strength overtime. The physiotherapist-supervised exercises after PRP had better effects on pain and knee function than the home-based exercises.

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