INTRODUCTION: Nordic walking training has many benefits in improving the condition of the disabled elderly. Then the aim of this study was to evaluate the effect of Nordic walking training on plasma levels of PGC1alpha and SIRT6 in elderly women with diabetes. MATERIALS AND METHODS: In this quasi-experimental study, 27 elderly women (age 65.45 +/- 2.70 years) with type 2 diabetes were selected and randomly divided into control groups (n = 14) and experimental groups (n = 13). Then, the experimental group performed exercise protocol of Nordic walking training, three days per week for eight weeks. Blood samples were collected before and after the training protocol. ELISA kit was used to measure the biochemical variables of the research. RESULTS: The analysis of data showed that the levels of PGC1alpha and SIRT6 in the exercise group compared to the control group increased significantly (p < 0.001) and glucose, insulin and resistance of insulin decreased significantly (p < 0.001). CONCLUSIONS: Nordic walking training, could reduce glucose, insulin and resistance insulin and increases PGC1alpha and SIRT6 in elderly women with diabetes, and help improve the metabolic system of the elderly.

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