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Effect of interesting respiratory rehabilitation training for the treatment of refractory Mycoplasma pneumoniae pneumonia in children
Li W, Liu T, Yao M, Yu R, Shu M, Zhang M, Huang J
BMC Infectious Diseases 2023 Aug 28;23(561):Epub
clinical trial
4/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

BACKGROUNDS: Refractory Mycoplasma pneumoniae pneumonia (RMPP) cause damage of pulmonary function and physical therapy assisting medical treatment is needed. OBJECTIVE: The aim of this study was to investigate the effect of interesting respiratory rehabilitation training on pulmonary function in children with RMPP. METHODS: A total of 76 children with diagnoses of RMPP in our hospital from January 2020 to February 2021 were enrolled in this prospective study. According to the random number table method, they were divided into the control group and the study group, with 38 cases in each group. The control group were given conventional treatment, and the study group received interesting respiratory rehabilitation training in the basis of conventional treatment. The antipyretic time, disappearance time of pulmonary shadow and cough, length of hospital stay, pulmonary function (first second of expiratory volume (FEV1), forced vital capacity (FVC), FEV1/FVC) at 1 day before and after intervention, serum interleukin-6 (IL-6), C-reactive protein (CRP), tumor necrosis factor (TNF-alpha), and quality of life (Pediatric Quality of Life Inventory, PedsQL 4.0 scale) were observed in the two groups. RESULTS: The antipyretic time, disappearance time of pulmonary shadow and cough, length of hospital stay in the study group were shorter than those in the control group (p < 0.05). One day before intervention, there was no significant difference in FVC, FEV1, FEV1/FVC IL-6, CRP, and TNF-alpha between the two groups (p > 0.05). One day after intervention, FVC, FEV1 and FEV1/FVC in the study group were better than those in the control group (p < 0.05), and the levels of IL-6, CRP, and TNF-alpha in the study group were lower than those in the control group with significant difference (p < 0.05). One day before intervention, there were no significant differences in physiological function, emotional function, social function, and school function between the two groups (p > 0.05). After intervention, physiological function, emotional function, social function, and school function of the study group were better than those of the control group (p < 0.05). CONCLUSION: The interesting respiratory rehabilitation training can effectively improve the pulmonary function of children with RMPP, with strong flexibility, which is worthy of clinical application.

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