BACKGROUND: High-intensity interval training (HIIT) is an effective exercise method that could lead to favorable changes in obese and diabetic subjects. OBJECTIVES: To investigate the effects of HIIT on serum omentin-1 levels, lipid profile, and insulin resistance in diabetic obese men. METHODS: Fifty obese men suffering from T2DM with ages between 40 and 60 years were enrolled. Subjects were divided into two groups: the HIIT (n = 26) and control group (n = 24). The HIIT group subjects underwent 12 weeks (3 sessions per week) of HIIT program, while the control group subjects kept to their normal daily activities. Fasting blood glucose levels, serum omentin-1 levels, lipid profile, and insulin resistance were evaluated at baseline and after the experiment. RESULTS: HIIT resulted in significant improvements in the subjects' body composition, serum omentin-1 levels, lipid profiles, fasting insulin, HOMA-IR (p < 0.05). Further, highly significant negative correlations were observed between serum omentin levels, on the one hand, and body mass index, body weight, and waist circumference, on the other. CONCLUSIONS: Twelve weeks of HIIT may be an effective training strategy to improve serum omentin-1 levels, body composition, lipid profile, and insulin sensitivity in diabetic obese men.

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