BACKGROUND AND AIMS: Persistent hyperglycemia, dyslipidemia, inflammation, and oxidative stress are important in cardiovascular risk in type-2 diabetes mellitus (DM). To evaluate the effect of 24-week yoga intervention on anthropometry and biochemical markers in DM patients, we performed a study. METHODS: A hospital-based prospective randomized study in 104 participants with DM divided into control (n = 52) and intervention (n = 52) groups was performed. Patients in the intervention group performed 40 min of multifaceted individualized yoga exercises 5 days/week for 24 weeks. Anthropometric measurements and biochemical analysis were performed at baseline and after 24 weeks in both groups. Descriptive statistics are reported. RESULTS: Baseline characteristics were similar in both groups. At 24 weeks, participants in the intervention versus controls had lower body mass index (25.6 +/- 2.9 versus 28.0 +/- 3.2 kg/m2), waist-hip ratio (0.94 +/- 0.06 versus 0.99 +/- 0.05), systolic blood pressure (121.2 +/- 11.7 versus 139.3 +/- 19.1 mmHg), fasting glucose (142.7 +/- 45.3 versus 175.7 +/- 45.4 mg/dL), glycated hemoglobin (7.2 +/- 1.8 versus 9.4 +/- 1.9%), low-density lipoprotein cholesterol (167.5 +/- 38.1 versus 192.2 +/- 51.4 mg/dL), nonhigh-density lipoprotein cholesterol (136.8 +/- 35.3 versus 158.6 +/- 47.2 mg/dL), interleukin-6 (32.0 +/- 21.5 versus 43.5 +/- 34.3 pg/mL), and high-sensitivity C-reactive protein (5.1 +/- 3.7 versus 9.5 +/- 15.6 mg/L) (p <= 0.05). In the intervention group, higher levels of high-density lipoprotein cholesterol (49.2 +/- 15.0 versus 40.4 +/- 7.2 mg/dL) and serum total antioxidants (1.9 +/- 0.4 versus 1.4 +/- 0.4 mmol/L) were observed (p < 0.001). CONCLUSION: A short-term yoga intervention led to reduced glycemia, dyslipidemia, and inflammatory markers and increased antioxidant status in patients with type-2 DM.

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