BACKGROUND: Multiple comorbidities and physiological changes play a role in a range of heart failure conditions and influence the most effective approach to exercise-based rehabilitation. This research aimed to examine and compare the outcomes of continuous training at three different intensities, focusing on left ventricular (LV) remodeling, functional capacity, and quality of life among patients with heart failure with reduced ejection fraction (HFrEF). METHODS: In this randomized control trial, a total of 60 male patients (average age 54.33 +/- 2.35 years) with HFrEF were randomly allocated into three groups: (1) High-intensity continuous training group (HICT), (2) Moderate-intensity continuous training group (MICT), and (3) Low-intensity continuous training group (LICT). All the training was performed on a bicycle ergometer 3 times/week for 12 weeks. Echocardiographic parameters (left ventricular ejection fraction, left ventricular end-diastolic dimension, left ventricular end-systolic dimension, N-terminal pro-B-type natriuretic peptide (NT-proBNP), quality of life (Minnesota Living with Heart Failure Questionnaire), and functional capacity (6-minute walking test) were assessed before and the end of the study. RESULTS: The HICT group demonstrated the greatest improvements in all measured variables when compared to the other two groups (p < 0.05). These findings were consistent across all measured outcomes. CONCLUSION: It was determined that HICT appears to yield the most favorable outcomes in enhancing echocardiographic measures, NT-proBNP levels, quality of life, and functional capacity among HFrEF patients.

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