BACKGROUND: This systematic review and meta-analysis aimed to compare the effects of high-intensity interval exercise (HIIE) with different recovery modes versus moderate-intensity continuous exercise (MICE) on cardiac troponin (cTn) elevation. METHODOLOGY: A literature search was conducted in four databases: Scopus, PubMed, EBSCO and Web of Science from January 2010 to June 2022. The articles were screened, evaluated for quality before data were extracted. The review protocol was registered at PROSPERO (CRD42021245649). Standardized mean differences (SMD) of peak cTn were analyzed with a 95% confidence interval (95% CI) using Revman 5.4 software. RESULTS: Six studies satisfied the inclusion criteria with a total of 92 and 79 participants for HIIE and MICE, respectively. Overall, there was no significant difference between HIIE and MICE in the elevation of cardiac troponin T (SMD 0.41 (95% CI (-0.21 to 1.03)), p = 0.20, I2 77%, p for heterogeneity < 0.01). In subgroup analysis, HIIE with passive recovery elicits greater release of cardiac troponin T than MICE (SMD 0.85 (95% CI (0.44 to 1.27)), p < 0.01, I2 32%, p for heterogeneity = 0.22). Changes of cardiac troponin T (SMD 0.41 (95% CI (-0.21 to 1.03)), p = 0.20, I2 77%, p for heterogeneity < 0.01) after HIIE with active recovery were not significantly different from those of MICE. CONCLUSIONS: There was no significant difference between HIIE and MICE in the elevation of cardiac troponin T. However, HIIE with passive recovery elicited more cardiac troponin T elevation than MICE, which should be considered when developing exercise programs.

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