PURPOSE: To systematically evaluate the effect of exercise rehabilitation as an adjuvant to clinical treatment for myofascial trigger points (MTrPs). PATIENTS AND METHODS: ESBCO, PubMed, Science Direct, Web of Science, China Knowledge Network (CNKI), and Wanfang databases were comprehensively searched from database inception date through July 2022. Randomized controlled trials comparing MTrPs treatments that included exercise rehabilitation with a single clinical treatment. Two researchers independently screened articles using inclusion/exclusion criteria, scored methodologic quality, and extracted data including patient demographics, interventions, and outcomes. RESULTS: We included 14 RCTs (N = 734). Results showed short-term (mean difference (MD) -2.25, 95% confidence interval (CI) -4.08 to -0.41, Z 2.40, p = 0.02) and long-term (MD -0.47, 95% CI -0.80 to -0.17, Z 3.05, p = 0.02) adjuvant exercise rehabilitation treatments were superior in reducing musculoskeletal pain intensity to single clinical treatment in controls, but long-term versus short-term effectiveness was not significantly different. The exercise rehabilitation group more effectively increased the range of motion (ROM) (standardized mean difference (SMD) 1.04, 95% CI 0.32 to 1.77; Z 2.84, p = 0.005) and decreased dysfunction (SMD -0.93, 95% CI -1.82 to -0.05, Z 2.06, p = 0.04) than controls; no significant difference was observed in the pressure pain threshold (PPT) between two groups. CONCLUSIONS: Exercise rehabilitation as an adjuvant to clinical treatment for MTrPs was moderately effective in relieving pain intensity, increasing ROM, and improving dysfunction versus single clinical intervention. These findings must be validated by larger, higher-quality studies.

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