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Unlocking the power of synergy: high-intensity functional training and early time-restricted eating for transformative changes in body composition and cardiometabolic health in inactive women with obesity |
Ameur R, Maaloul R, Tagougui S, Neffati F, Hadj Kacem F, Najjar MF, Ammar A, Hammouda O |
PLoS ONE 2024 May;19(5):e0301369 |
clinical trial |
5/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed* |
OBJECTIVE: The purpose of this study was to examine the long-term effects of time-restricted eating (TRE), with or without high intensity functional training (HIFT), on body composition and cardiometabolic biomarkers among inactive women with obesity. METHODS: Sixty-four women (BMI 35.03 +/- 3.8 kg/m2; age 32.1 +/- 10 years) were randomly allocated to either: (1) TRE (<= 8-h daily eating window, with ad libitum energy intake) group; (2) HIFT (3 sessions/week) group; or (3) TRE combined with HIFT (TRE-HIFT) group. The interventions lasted 12 weeks with a pre-post measurement design. A HIFT session consists of 8 sets of multiple functional exercises with self-selected intensity (20 or 30s work/10s rest). RESULTS: TRE-HIFT showed a greater decrease of waist and hip circumferences and fat mass compared to TRE (p = 0.02, p = 0.02 and p < 0.01; respectively) and HIFT (p = 0.012, p = 0.028 and p < 0.001; respectively). Weight and BMI decreased in TRE-HIFT compared to HIFT group (p < 0.001; for both). Fat-free mass was lower in TRE compared to both HIFT and TRE-HIFT groups (p < 0.01 and p < 0.001; respectively). Total cholesterol, triglyceride, insulin, and HOMA-IR decreased in TRE-HIFT compared to both TRE (p < 0.001, p < 0.01, p = 0.015 and p < 0.01; respectively) and HIFT (p < 0.001, p = 0.02, p < 0.01 and p < 0.001; respectively) groups. Glucose level decreased in TRE-HIFT compared to HIFT (p < 0.01). Systolic blood pressure decreased significantly in both TRE-HIFT and HIFT groups compared to TRE group (p = 0.04 and p = 0.02; respectively). CONCLUSION: In inactive women with obesity, combining TRE with HIFT can be a good strategy to induce superior effects on body composition, lipid profile and glucose regulation compared with either diet or exercise intervention alone. TRIAL REGISTRATION: Clinical Trials Number: PACTR202301674821174.
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