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Unlocking the power of synergy: high-intensity functional training and early time-restricted eating for transformative changes in body composition and cardiometabolic health in inactive women with obesity
Ameur R, Maaloul R, Tagougui S, Neffati F, Hadj Kacem F, Najjar MF, Ammar A, Hammouda O
PLoS ONE 2024 May;19(5):e0301369
clinical trial
5/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

OBJECTIVE: The purpose of this study was to examine the long-term effects of time-restricted eating (TRE), with or without high intensity functional training (HIFT), on body composition and cardiometabolic biomarkers among inactive women with obesity. METHODS: Sixty-four women (BMI 35.03 +/- 3.8 kg/m2; age 32.1 +/- 10 years) were randomly allocated to either: (1) TRE (<= 8-h daily eating window, with ad libitum energy intake) group; (2) HIFT (3 sessions/week) group; or (3) TRE combined with HIFT (TRE-HIFT) group. The interventions lasted 12 weeks with a pre-post measurement design. A HIFT session consists of 8 sets of multiple functional exercises with self-selected intensity (20 or 30s work/10s rest). RESULTS: TRE-HIFT showed a greater decrease of waist and hip circumferences and fat mass compared to TRE (p = 0.02, p = 0.02 and p < 0.01; respectively) and HIFT (p = 0.012, p = 0.028 and p < 0.001; respectively). Weight and BMI decreased in TRE-HIFT compared to HIFT group (p < 0.001; for both). Fat-free mass was lower in TRE compared to both HIFT and TRE-HIFT groups (p < 0.01 and p < 0.001; respectively). Total cholesterol, triglyceride, insulin, and HOMA-IR decreased in TRE-HIFT compared to both TRE (p < 0.001, p < 0.01, p = 0.015 and p < 0.01; respectively) and HIFT (p < 0.001, p = 0.02, p < 0.01 and p < 0.001; respectively) groups. Glucose level decreased in TRE-HIFT compared to HIFT (p < 0.01). Systolic blood pressure decreased significantly in both TRE-HIFT and HIFT groups compared to TRE group (p = 0.04 and p = 0.02; respectively). CONCLUSION: In inactive women with obesity, combining TRE with HIFT can be a good strategy to induce superior effects on body composition, lipid profile and glucose regulation compared with either diet or exercise intervention alone. TRIAL REGISTRATION: Clinical Trials Number: PACTR202301674821174.

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