AIM: To explore the individual response to a multimodal intervention on quality of life (QOL) and disability. METHODS: 843 (77.83 years, 50.65% men) prefrail and frail individuals >= 70 years with type 2 diabetes mellitus. Participants were randomized to the usual care group (UCG) or the multicomponent intervention (IG). Intervention consisted in 16-week progressive resistance training program, 7 educational sessions and the achievement of HbA1c (7 to 8%, 53 to 64 mmol/mol)) and BP (< 150 mmHg) targets. QOL (EuroQol EQ-5D-5L), basic (Barthel Index, BI) and instrumental (Lawton and Brody Index) activities of daily living (ADL) were assessed. Multivariate binomial and multinomial logistic regression models were used to explore the effect of the IG, and adherence on the outcomes studied. RESULTS: The IG was associated with a significant higher probability of improvement in the QOL (OR (95% CI) 1.75 (1.20 to 2.54), p-value = 0.004) and a lower probability of deterioration in QoL (0.61 (0.87 to 0.54), 0.006) and Barthel Index (0.59 (0.37 to 0.93), 0.023). A high adherence (>= 93%) was needed to achieve benefits in the QOL while > 84.38% was needed for achieving the benefits in Barthel Index. CONCLUSIONS: IG has proven to be effective in increasing QOL and avoiding the worsening of QOL and basic ADL.
With permission from Excerpta Medica Inc.

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