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The effects of multicomponent exercise on mild cognitive impairment in elderly population: a randomized control trial
Khattak HG, Arshad H, Aman S, Amjad I
Journal of Medical Sciences (Peshawar) 2024 Sep;32(3):221-225
clinical trial
6/10 [Eligibility criteria: No; Random allocation: Yes; Concealed allocation: Yes; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

OBJECTIVE: To determine the effectiveness of multicomponent exercise on mild cognitive impairment in older adults. MATERIALS AND METHODS: This randomized control trial was conducted at the Department of Rehabilitation at Pakistan Railway General Hospital, Rawalpindi. Fifty-eight older persons with mild cognition impairment were allocated randomly into 2 groups. The participants of the experimental group (n = 29) performed multicomponent exercises two times a week for 55 to 60 minutes. In the control group (n = 29), participants performed 20 minutes of treadmill walking thrice a week. Both groups performed these exercises for 6 weeks. Pre and post assessment was carried out at baseline and after 6 weeks of intervention for the following test: Mini-mental state examination (MMSE), Montreal Cognitive Assessment (MoCA), Trail-making test A (TMT-A) and Trail making test-B (TMT-B). Data was analyzed using SPSS 21. RESULTS: The mean age of study participants was 62.74 +/- 7.4 years. Within-group analysis for MMSE, MoCA, TMT-A, and TMT-B significantly improved (p < 0.05) in the experimental group in comparison to the control group. Between-group analysis showed that all parameters were significantly improved (p < 0.05) at post-intervention assessment. CONCLUSIONS: Multicomponent exercise training was found to be effective in the elderly with mild cognitive impairment. A combination of exercise can enhance cognitive function, help in the prevention of the decline in cognitive function, and reduce the risk for dementia.

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