OBJECTIVE: to determine the effects of aerobic training in randomized controlled clinical trials on functional capacity, motor symptoms, and oxygen consumption in individuals with PD through a systematic literature review and meta-analysis. DATA SOURCES: PUBMED, Web of Science, CINAHL, SciELO, and Medline databases were searched to identify published studies until September 2023. STUDY SELECTION: Randomized controlled clinical trials that evaluated the long-term effect of aerobic exercise in individuals with PD were included. DATA EXTRACTION: Two independent reviewers extracted the data, assessed the risk of bias and the Grading of Recommendation Assessment, Development, and Evaluation (GRADE). In case of disagreement, a third reviewer was consulted. DATA SYNTHESIS: 13 studies were included in the systematic review and the number of participants was 588 with an average age of 66.2 years (57 to 73 years). The study's exercise intervention lasted between 6 to 70 weeks, with most studies lasting 10 to 12 weeks, with three sessions/week and an average duration of 47 minutes/session. The meta-analysis revealed that aerobic exercise is effective in enhancing maximal oxygen uptake (SMD 0.42 (CI95% 0.18 to 0.66; p = 0.0007)) and functional capacity (SMD 0.48 (CI95% 0.24 to 0.71; p < 0.0001)). In addition, aerobic exercise can reduce the UPDRS III (mean difference -2.48 (CI95% -3.16 to -1.81; p < 0.00001)) score in individuals with PD. CONCLUSION: Aerobic exercise training conducted 2 to 3 times a week, with different intensities (low to high) can be an effective intervention for enhancing functional capacity, maximizing oxygen uptake, and reducing the UPDRS scores in individuals with Parkinson's disease (PD).

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