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The short-term effect of spinal manipulation in the treatment of infantile colic: a randomized controlled clinical trial with a blinded observer
Wiberg JMM, Nordsteen J, Nilsson N
Journal of Manipulative and Physiological Therapeutics 1999 Oct;22(8):517-522
clinical trial
4/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

OBJECTIVE: To determine whether there is a short-term effect of spinal manipulation in the treatment of infantile colic. DESIGN: A randomized controlled trial. SETTING: A private chiropractic practice and the National Health Service's health visitor nurses in the suburb Ballerup (Copenhagen, Denmark). SUBJECTS: Infants seen by the health visitor nurses, who fulfilled the diagnostic criteria for infantile colic. INTERVENTION: One group received spinal manipulation for 2 weeks, the other was treated with the drug dimethicone for 2 weeks. OUTCOME MEASURE: Changes in daily hours of crying as registered in a colic diary. RESULTS: By trial days 4 to 7, hours of crying were reduced by 1 hour in the dimethicone group compared with 2.4 hours in the manipulation group (p = 0.04). On days 8 through 11, crying was reduced by 1 hour for the dimethicone group, whereas crying in the manipulation group was reduced by 2.7 hours (p = 0.004). From trial day 5 onward the manipulation group did significantly better that the dimethicone group. CONCLUSION: Spinal manipulation is effective in relieving infantile colic.
Reprinted from the Journal of Manipulative and Physiological Therapeutics with copyright permission from the National University of Health Sciences.

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