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Domiciliary oxygen for interstitial lung disease (Cochrane review) [with consumer summary]
Crockett A, Cranston JM, Antic N
Cochrane Database of Systematic Reviews 2001;Issue 3
systematic review

BACKGROUND: Retrospective survival data have suggested poor effectiveness of oxygen therapy in patients with interstitial lung disease (ILD). OBJECTIVES: To determine the effect of domiciliary oxygen therapy on survival and quality of life in patients with a diagnosis of ILD and hypoxaemia. SEARCH STRATEGY: Randomized controlled trials (RCTs) were identified from searches of CENTRAL, Medline and Embase. Searches were current as of October 2009. SELECTION CRITERIA: Any randomized controlled trial (RCT) in adult patients with hypoxaemia and ILD that compared long term domiciliary or home oxygen therapy with a control group. DATA COLLECTION AND ANALYSIS: Studies were assessed by two authors. Data were entered into Review Manager 5 and analysed. MAIN RESULTS: Only one trial met the eligibility criteria of the review. Mortality for both the oxygen treated and control groups was approximately 91% after 3 years (Peto odds ratio 0.99, 95% confidence intervals 0.16 to 6.26). The effect of oxygen therapy on quality of life and physiological parameters was not reported. AUTHORS' CONCLUSIONS: The assumption that home oxygen therapy has a beneficial survival effect in patients with ILD has not been demonstrated in the single RCT identified.

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